申博体育平台

生科院潘飞燕-郭志刚课题组揭示“组蛋白密码”在DNA氧化损伤修复中的新机制

2020nian7yue29ri,shengkeyuanpanfeiyan-guozhigangjiaoshouketizuzaidnasunshangxiufufangmiandeyanjiuchengguoyi“symmetrical dimethylation of h4r3: a bridge linking dna damage and repair upon oxidative stress "weitizaixianfabiaozairedox biologyzazhishang,gaizazhishiyanghuahaiyuanlingyudezuiquanweiqikan,yingxiangyinzi9.986。shuoshishengmazhuang、wangwentaoweilunwendegongtongdiyizuozhe,panfeiyanfujiaoshouheguozhigangjiaoshouweibinglietongxunzuozhe。lunwenlianjie: 。

申博体育平台zaishengminghuodongguochengzhong,xibaohuibuduanzaoshouneiyuanhewaiyuanyinsuyinqideyanghuayali,congerchanshengguoduodehuoxingyangfenzi(reactive oxygen species,ros),rosfeiteyixingdigongjibaokuodnahedanbaizhizaineideshengwudafenzi。qizhong,dnashizuizhuyaodebabiao,yanghuadednaruguobubeijishixiufu,huizaidnafuzhiguochengzhongxingchengcuopei,yinqijiyinzudebuwending,zuizhongdaozhizhongliujimouxietuixingxingjibingdefasheng。jitifazhanchuduotiaotujingduiyanghuasunshangdednajinxingxiufu,qizhongjianjiqiechuxiufu(ber)shixibaoneidnayanghuasunshangdezhuyaoxiufutujing。yanjiuberdanbairuhexiangyingyanghuayingjixinhaobingjinxingyouxugaoxiaodexiufuduiyulinchuangjibingfashengdejilijuyouzhongyaodelilunyiyihelinchuangjiazhi。

zudanbaizaitedingdeshengliqingkuangxiahuifashengfanyihouxiushi,congertigongyizhongshibiebiaozhi,weiqitadanbaiyudnadejiehechanshengxietonghuozhejiekangxiaoying,tongchangbeirenweiyuzhuanludiaokongmiqiexiangguan。shengkeyuanguozhigangjiaoshouketizuyanjiufaxian,zudanbaidefanyihouxiushibujincanyuzhuanludiaokong,zaidnasunshangxiufuzhongyejuyoujiweizhongyaodezuoyong。zaiyanghuayingjixia,zudanbaih4weibudisanweijingansuanduichengxingdejiajihuaxiushi(h4r3me2s)huixianzhushangsheng,qizaidnayanghuasunshangxiufuzhongchongdangzheqiaoliangjiaose: dnayanghuasunshangxinhaotongguo8-oxog/ogg1/prmt5chuandidaoh4r3me2s,h4r3me2sdechanshengyouliyuransezhijiegoudedakai,qijinyibuzhaomuxiufuguanjiandanbaifen1laizhixingdnaxiufugongneng,congerweichijiyinzudewending。gaiyanjiushenruchanmingle“zudanbaimima“jieshousunshangxinhaobingshuchuxinhaodeguocheng,duijitiruhezaiyanghuayingjixiaweichijiyinzuwendingxingtigonglegengweixizhidejieshi。


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    申博体育平台2020nian07yue31ri 11:24

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